Frontispiece: Modeling the Enzyme Specificity by Molecular Cages through Regulating Reactive Oxygen Species Evolution

Mechanism Regulating Reactive Oxygen

O 22: Reactive Oxygen Species and Epilepsy

Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...

Reactive oxygen species in the vasculature: molecular and cellular mechanisms.

Accumulating evidence indicates that reactive oxygen species (ROS) play major roles in the initiation and progression of cardiovascular dysfunction associated with diseases such as hyperlipidemia, diabetes mellitus, hypertension, ischemic heart disease, and chronic heart failure. ROS produced by migrating inflammatory cells as well as vascular cells (endothelial cells, vascular smooth muscle ce...

Production of Reactive Oxygen Species by Mitochondria

The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and reperfusion. Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes and reduces damage to mitochondria. We asked if ROS generation by intact mitochondria during t...

Reactive Oxygen Species Generation by Lunar Simulants

Introduction: The current interest in human exploration of the Moon and past experiences of Apollo astronauts has rekindled research into the harmful effects of Lunar dust on human health. While the mineralogical composition of lunar regolith has been well documented, other factors, such as partial melting due to space weathering, UV irradiation, and dryness may also contribute to the toxicity ...